ESTRATÉGIAS PARA A SÍNTESE DO ÁCIDO LISÉRGICO

STRATEGIES FOR THE SYNTHESIS OF LYSERGIC ACID. (+)-Lysergic acid [(+)-1] is a precursor of several substances with well-established pharmacological properties, including some drugs approved and commercialized around the world. Thus, importance (+)-1 as synthetic target becomes undoubted various strategies for synthesis its tetracyclic core have been reported in literature. Therefore, this review article we will address chronological order total formal syntheses lysergic (1), separating them into racemic chiral/asymmetric syntheses. Until now, there are 24 described literature, namely, 11 13 Considering all accomplished, 15 were planned to produce (±)-lysergic [(±)-1] 9 presented routes eventually provide (+)-lysergic [(+)-1]. A significant evolution regarding approaches efficiency may be observed since first (±)-1 until last asymmetric (+)-1.